解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:INTRODUCTION:Protocols using high levels of positive end-expiratory pressure (PEEP) in combination with low tidal volumes have been shown to reduce mortality in patients with severe acute respiratory distress syndrome (ARDS). However, the optimal method for setting PEEP is yet to be defined. It has been shown that resp...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10236
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. METHODS:The PubMed and EMBASE databases were searched using the search terms 'artificial respiration', 'instrumentation', 'device', 'devices', 'm...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc9969
更新日期:2011-01-01 00:00:00
abstract::Disagreements between the perceptions of nurses and physicians regarding end-of-life (EOL) decisions are frequent. In a survey carried out in 13 Brazilian ICUs, Fumis and Deheinzelin reported that the majority of nurses, physicians and family members are in favor of limiting life-sustaining therapies in terminally ill...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9962
更新日期:2011-01-01 00:00:00
abstract::Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10067
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can pre...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10568
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases. METHODS:According to the National Health Insurance Research Database of Taiwan, there were 8,906...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10128
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Partial pressure of end-tidal carbon dioxide (PetCO2) during cardiopulmonary resuscitation (CPR) correlates with cardiac output and consequently has a prognostic value in CPR. In our previous study we confirmed that initial PetCO2 value was significantly higher in asphyxial arrest than in ventricular fibri...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9417
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10100
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Thrombomodulin, which is expressed solely on monocytes, along with tissue factor (TF), takes part in coagulation and inflammation. Circulating blood monocytes can be divided into 3 major subtypes on the basis of their receptor phenotype: classical (CD14brightCD16negative, CMs), inflammatory (CD14brightCD16...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10139
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Monitoring of hemodynamic and volumetric parameters after severe burns is of critical importance. Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility of continuous monitoring with minimally invasive transpulmonary thermodilution (TPTD) in severely ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10147
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Our aim was to evaluate the role of B-type natriuretic peptide (BNP) percentage variations at 24 hours and at discharge compared to its value at admission in order to demonstrate its predictive value for outcomes in patients with acute decompensated heart failure (ADHF). METHODS:This was a multicenter Ita...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc9067
更新日期:2010-01-01 00:00:00
abstract::Prone ventilation (PV) is a ventilatory strategy that frequently improves oxygenation and lung mechanics in critical illness, yet does not consistently improve survival. While the exact physiologic mechanisms related to these benefits remain unproven, one major theoretical mechanism relates to reducing the abdominal e...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9099
更新日期:2010-01-01 00:00:00
abstract::The great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for ...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/cc8846
更新日期:2010-01-01 00:00:00
abstract::In this month's issue of Critical Care, Determann and colleagues report the results of a randomized controlled trial comparing the effects of mechanical ventilation (MV) with two tidal volumes (6 versus 10 ml/kg predicted body weight) on cytokine levels in lung lavage fluid and plasma as a surrogate for early identifi...
journal_title:Critical care (London, England)
pub_type: 社论
doi:10.1186/cc8842
更新日期:2010-01-01 00:00:00
abstract::Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neur...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/cc8847
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Mechanical ventilation (MV) with high tidal volumes may induce or aggravate lung injury in critical ill patients. We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in patien...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc8919
更新日期:2010-01-01 00:00:00
abstract::Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9256
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear. METHODS:A meta-analysis was conducted of randomized controlled trials evaluating AKI after infusion of hyperoncotic albumin and hydroxyethyl starch (...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/cc9308
更新日期:2010-01-01 00:00:00
abstract::Since the inception of blood banking, refinements in laboratory processes have allowed for progressively longer storage times of red blood cells. Whilst advantageous for the logistics of stock management, the clinical impact of the duration of red blood cell storage prior to transfusion remains uncertain, and a topic ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8878
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Lymphocyte apoptosis has been suggested to play a central role in sepsis pathophysiology, and studies in animal models demonstrated that blocking this pathway improves outcome. However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the differe...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9181
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Data on the epidemiology and management of anorexia nervosa (AN) in the intensive care unit (ICU) are scarce. The aim of this study was to evaluate the prevalence and associated morbidity and mortality of AN in French ICUs. METHODS:We randomly selected 30 ICUs throughout France. Thereafter, we retrospecti...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/cc9274
更新日期:2010-01-01 00:00:00
abstract::Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with ce...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc9236
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:A lack of data exists in the literature evaluating acidemia on admission as a favorable or negative prognostic factor in patients with acute cardiogenic pulmonary edema (ACPE) treated with non-invasive continuous positive airway pressure (CPAP). The objective of the present study was to investigate the imp...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9315
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc8909
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9390
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates. METHODS:This retrospective analysis included trauma patients who received >or= 5 units of red blood cell concentrate within 24 hours. C...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8948
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for final pathogen identification and antimicrobial susceptibility testing. We organized a prospective observational multicenter study in three study site...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9234
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Following trauma, patients may suffer an overwhelming pro-inflammatory response and immune paralysis resulting in infection and multiple organ failure (MOF). Various potentially immunomodulative interventions have been tested. The objective of this study is to systematically review the randomized controlle...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9218
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Neutrophil gelatinase-associated lipocalin (NGAL) is a promising novel biomarker that correlates with the severity and outcome of acute kidney injury (AKI). However, its prognostic utility during the late course of AKI, especially in patients that require renal replacement therapy (RRT) remains unknown. Th...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8861
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. METHODS:Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 ser...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc9001
更新日期:2010-01-01 00:00:00
abstract::In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets), endothelial and smooth muscle cells. Microparticles are proinflammatory and procoagulant fragments originating from plasma membrane generated after cellular activation a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9231
更新日期:2010-01-01 00:00:00
abstract::Type 2 diabetes has reached epidemic proportions in many parts of the world. The disease is projected to continue to increase and double within the foreseeable future. Dysglycaemia develops in the form of hyperglycaemia, hypoglycaemia and marked glucose variability in critically ill adults whether they are known to ha...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9266
更新日期:2010-01-01 00:00:00
abstract::Chloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literatur...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9052
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9393
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9061
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Lowering of hyperglycemia in the intensive care unit (ICU) is widely practiced. We investigated in which way glucose regulation, defined as mean glucose concentration during admission, is associated with ICU mortality in a medical and a surgical cohort. METHODS:Retrospective database cohort study includin...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9369
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury. METHODS:Twenty-one sheep (37 ± 2 ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc9342
更新日期:2010-01-01 00:00:00
abstract::Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO2 represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common - and generally underappreciated - component of many disease states, including early asthma, high-altitude pulmo...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8926
更新日期:2010-01-01 00:00:00
abstract::Owing to an increasing focus on the rising cost of medical care in the United States, bending the cost curve has become the central tenet of healthcare reform. The exact definition of this phrase, however, remains elusive. In order to affect change in the cost and quality of healthcare, the importance of comparative e...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc9045
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Although less invasive than pulmonary artery catheters (PACs), arterial pulse pressure analysis techniques for estimating cardiac output (CO) have not been simultaneously compared to PAC bolus thermodilution CO (COtd) or continuous CO (CCO) devices. METHODS:We compared the accuracy, bias and trending abil...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9335
更新日期:2010-01-01 00:00:00